The 10th seed, the oldest in the Rome Masters draw at 35, lost 6-0, 7-6 (2) to Musetti who is ranked 249th in the world.
Zinedine Zidane's side didn't play in the first round of matches one week ago, after their game at home to Getafe was postponed in order to allow them more time to recover after their participation in last season's Champions League in August.
Real Sociedad were a bit flat in their opening day 1-1 draw away to Real Valladolid, but should be sharper after that game and another week's training, and although the stands of the Reale Arena will again be devoid of fans on Sunday night, this should be a tough test of Madrid's ability to defend their title. Enditem
Flamengo had never before lost a Copa Libertadores match by a five-goal margin. Previously, their worst showing in South America's premier club competition was a 5-1 capitulation to Gremio in 1984. Thursday's result was also the heaviest defeat by defending Copa Libertadores champions.
In the opening round of CONMEBOL qualifiers, Colombia host Venezuela, Uruguay are home to Chile, Bolivia visit Brazil, Paraguay welcome Peru and Ecuador travel to Argentina. Enditem
According to the anonymous source, the top European soccer leagues like La Liga and Bundesliga have made agreements to Chinese broadcasters for lowering price, considering the financial reality during the coronavirus pandemic.
"We have been able to act quickly and decisively. We have prepared the COVID-19 Relief Plan for a global value of 1.5 billion US dollars. This is unprecedented," said Infantino.
Djokovic beat Norway's Casper Ruud 7-5, 6-3. The Serb will face eight-seeded Argentine Diego Schwartzman in the men's final.
In the opening game, the Viola scored the winner in the 78th minute as Gaetano Castrovilli tapped in from Federico Chiesa's assist.
This week saw Koeman's men beat Girona 3-1 in another preparation game, but Saturday will be their last chance to get things right before things are for real next week.
Elsewhere on Tuesday, Ecuador's LDU Quito secured a 1-0 win away to Peru's Binacional, courtesy of a first-half goal from Matias Zunino.